Acetamide, 2-hydroxy-N-methyl-N-phenyl-
2-HYDROXY-N-METHYL-N-PHENYL-ACETAMIDE
CAS: 42404-09-1
Molecular Formula: C9H11NO2
Acetamide, 2-hydroxy-N-methyl-N-phenyl- - Names and Identifiers
| Name | 2-HYDROXY-N-METHYL-N-PHENYL-ACETAMIDE |
| Synonyms | N-METHYL HYDROXY ACETANILIDE 2-HYDROXY-N-METHYL-N-PHENYL-ACETAMIDE Acetamide, 2-hydroxy-N-methyl-N-phenyl- |
| CAS | 42404-09-1 |
| EINECS | 255-804-6 |
Acetamide, 2-hydroxy-N-methyl-N-phenyl- - Physico-chemical Properties
| Molecular Formula | C9H11NO2 |
| Molar Mass | 165.19 |
| Physical and Chemical Properties | This product is colorless liquid, m.p.52 ~ 53 ℃, soluble in water, acetone, insoluble in petroleum ether, alkane and other organic solvents. |
Acetamide, 2-hydroxy-N-methyl-N-phenyl- - References
| Use | N-methylhydroxyacetanilide is an intermediate of the herbicide mefenamide. |
| production method | the preparation method is to add chloroacetic acid, toluene and phosphorus oxychloride into the reaction kettle in sequence and heat to a certain temperature, add N-methyl aniline Dropwise within the specified time, after the end of the addition of heat preservation for several hours, cooling and washing to neutral, under reduced pressure to remove dissolved N-methyl chloroacetanilide, then chloroacetanilide, methanol and sodium acetate were added to another reaction kettle, stirred, and heated to a certain temperature, the reaction was carried out for several hours, after the reaction was finished, water was washed, and the organic layer was methanol removed under normal pressure to obtain acetanilide acetate. The product, liquid alkali and water were sequentially added to the reaction kettle, heated to a certain temperature, and the hydrolysis reaction was carried out, the reaction crystallization was layered, the organic layer was put into the crystallization kettle, and the product was obtained by cooling the crystallization. |
Last Update：2024-04-09 21:21:28
